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10.1016/j.prmcm.2022.100173 577

However, an experimental evidence of cytokine type released after ozone therapy application is needed

doi: 10.1515/BC.2009.033 4 CavalcantiY

However, critical evaluation requires acknowledging limitations: many studies lack the sample sizes and rigorous controls standard for Western regulatory purposes, independent replication has been limited, and long-term safety data in large human cohorts is lacking