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This is one of the reasons why research into IGF-1 levels offers such contradictory results

The anti-estrogen receptor drug, tamoxifen, is selectively Lethal to P-glycoprotein-expressing Multidrug resistant tumor cells

Although vitamin K has a low potential for toxicity, it can interact with certain medications, such as warfarin and antibiotics ( SUMMARY Both water- and fat-soluble vitamins can cause side effects when taken in high doses, with some causing more severe symptoms than others

A notable application of the Gut Chip is to investigate the crosstalk between the immune system and the microbiome, a hallmark of chronic inflammatory diseases including IBD (Kim et al., 2016)