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Cellular senescence: "Zombie cells" that secrete inflammatory factors, promoting further aging

We confirm that co-treatment with 5FU and mitochondrial inhibitors, particularly CI inhibitors IACS-010759 (a specific CI inhibitor under clinical evaluation 51 ) and metformin hydrochloride (a treatment for diabetes that inhibits CI 52 ), increases growth arrest and death in CRC cells (Fig

Supplementary Table 3 (download XLSX Concentration of compounds and probes used in pulldown experiments

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