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NRF2 redirects glutamate to glutathione synthesis and cystine uptake and away from TCA cycle anaplerosis, therefore limiting glutamate as a carbon source for TCA cycle and mitochondrial activity (Sayin et al

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Recently, a mechanistic link was proposed in which patients who develop ICIs-related irAEs derive a survival benefit compared to those who do not, suggesting an overlap between toxicities and the treatment efficacy

The weight-lowering effect is likely mediated by enhanced energy expenditure 23 , modulation of the gut microbiota leading to increased fecal energy excretion 24 , and fermentation of dietary fiber into SCFAs, which promote lipid oxidation and suppress systemic lipogenesis 25