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Risks and Side Effects While generally safe, vitamin B12 injections can have side effects or risks, such as: Mild pain, swelling, or redness at the injection site Dizziness, headache, or nausea Allergic reactions (rare) Hypokalemia (low potassium levels) in individuals with severe deficiency undergoing treatment People with allergies to cobalt or who have Lebers disease should avoid B12 injections unless specifically advised by a doctor

The B12 found in supplements typically doesn't need stomach acid to be absorbed

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The injection itself is usually hydroxocobalamin, which the UK prefers over cyanocobalamin because it stays in the body longer, as set out in the BNF entry