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GHK-Cu is a naturally occurring copper-binding tripeptide investigated in laboratory research for its effects on skin regeneration, collagen synthesis models, and anti-inflammatory pathways

In autoimmune hepatitis and T-cell-mediated hepatitis models, gut microbiota-derived ICA induces the expression of PI3K-interacting protein 1 by activating AhR in CD8 + T cells, thereby inhibiting the PI3K/Akt/mTOR pathway, limiting excessive activation of effector T cells, and attenuating liver injury

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