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If side effects are intolerable at any dose, the standard approach is to reduce back to the last tolerated dose and remain there for an additional four weeks before attempting escalation again

To this end, BALB/c mice, which are genetically deficient in endogenous melatonin production (28), were intranasally challenged with 25 g Alternaria alternata (AA) or PBS daily for four days, with or without concurrent intraperitoneal melatonin treatment using established protocols described previously (18, 2931) ( Figure 1A )

Inhibitors of glutathione S -transferases as therapeutic agents