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Immune cells in the central nervous system called microglia can become activated by chronic inflammation, infection, trauma, or autoimmune dysfunction

There are also strains under development that have been genetically engineered to secrete immunomodulators, which have the potential to favorably influence the immune system

This hypothesis is supported by the data that Fas-mediated cell death in mature erythrocytes can be triggered by internal stimuli like ROS and p38 MAPK signaling [194,195,196]

The regulatory environment continues to evolve, and patients should stay informed about current availability through their prescribers and pharmacies