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Taken together, these findings suggest that Nrf2 plays a vital role in mediating the chondroprotective effects of metformin by means of anti-oxidation, and that loss of Nrf2 substantially attenuates, but does not completely abolish, the therapeutic efficacy of metformin in the MIA-induced OA model

Understanding these changes is essential for clinicians aiming to deliver effective, evidence-informed rehabilitation and conditioning interventions for women during the menopause transition

February 2024 Judge Cote dismissed nearly all the claims in the New York MDL, according to an order we reviewed

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