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After the onset of the disease, the child received fluid replenishment and other symptomatic treatments at a local hospital, but the symptoms did not significantly improve

In the original mouse work it was described as well-tolerated, but that is the limit of the in-vivo safety evidence, and it is mouse-only

Before clinical application, it will be critical to develop reliable companion diagnostics to determine the activity state of SQOR in a patients lesion and the cells dependence on SQOR, in order to guide whether SQOR should be inhibited or activated for therapy

ADI-PEG20 treatment may lead to stable disease but reduction in tumor progression was not observed, although these phenomena may require larger scale of study with longer observation period for further verification [26, 131]